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沥青基球状活性炭的医用性能评价

注意：本论文已在《新型炭材料》2002,17(3):11-14发表
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沥青基球状活性炭的医用性能评价
吕春祥1 , 　李开喜1 , 　吕永根1 , 　梁晓怿1 , 　宋　燕1 ,凌立成1 , 　王占仁2 , 　国建琴2
(1. 中国科学院山西煤炭化学研究所, 山西太原　030001 ; 　2. 廊坊爱尔血液净化器材厂, 河北廊坊　065000)

摘要：表征了沥青基球状活性炭的基本结构参数(如比表面积、孔容量、球形度、强度、重金属含量等) ,测定了 其对血液中典型中、小毒性分子的吸附性能(肌酐和VB12 ) 和溶血反应率,分析了以沥青基球状活性炭为吸附剂的 人工炭肾的微粒释放量、热源和细菌含量,并进行临床试验。结果表明:沥青基球状活性炭球形度好,强度高,具有 良好的广谱吸附性能,对血液中典型的中、小毒性分子吸附能力强,重金属含量低,溶血率低,微粒释放量少,无热 源、无菌,血液灌流临床试验效果满意,可以作为人工炭肾的吸附剂。
关键词：沥青基球状活性炭; 吸附; 溶血反应; VB12 ; 肌酐
文章编号: 　100728827(2002) 0320011204

THE MEDICAL PERFORMANCE OF PITCH2BASED SPHERICAL ACTIVATED CARBON

Abstract : The basic structural parameters of pitch2based spherical activated carbon (PSAC) were characterized ,such as specific surface area by BET model , total pore volume , micropore and mesopore volume , sphericity , hardness and content of heavy metal ions . Its adsorption capacity to creatinine and vitamin B 12 , which are typical small and medium toxic molecules in blood , were measured. Hemolysis ratio , number of particles released , pyrexic source and germ count in a man2made kidney made of PSAC were checked . The results showed that PSAC had many excellent properties such as high hardness , large adsorption range , good adsorbing ability to typical toxic molecules in blood ,low content of heavy metalions , low hemolysis ratio , few released particles and no pyrexic source and germs . Satisfactory results have been obtained in clinical experiments for blood purification , which show that PSAC can be used as an adsorbent for a man-made kidney.
Key words : itch-based spherical activated carbon ; Adsorption ; Homolysis ; Vitamin B12 ; Creatinine

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