CIMS论文的天地

 

Association of vitamin D receptor gene polymorphisms in Chinese patients with generalized aggressive periodontitis

注意:本论文已在《J Periodont Res》, 2008, 43(3): 360-363 发表
使用者请注明论文出处

Medical School of Jing gangshan University , Ji’an 343000 , China

Association of vitamin D receptor gene polymorphisms in Chinese patients with generalized aggressive periodontitis.
Background and Objective: The clinical features suggest that genetic factors may have a strong influence on susceptibility to aggressive periodontitis. The aim of this study was to investigate the association of vitamin D receptor gene polymorphisms with generalized aggressive periodontitis in Chinese patients.Material and Methods: A restriction fragment length polymorphism (RFLP) for 10,438,141 C to T (rs1544410, BsmI), 10,382,063 A to G (rs731236, TaqI),10,382,143 C to A (rs7975232, ApaI) and 10,416,201 A to G (rs2228570, FokI) of vitamin D receptor gene was analysed by polymerase chain reaction, followed by digestion with restriction enzymes and gel electrophoresis. The genotypes of 51 generalized aggressive periodontitis patients and 53 periodontally healthy control subjects were analysed. The genotypic and allelic frequencies of each polymorphism site for the patients and control subjects were compared.
Results: The distribution of vitamin D receptor FokI genotypes and alleles between the two groups was significantly different (p ? 0.043 and p ? 0.012,respectively). The F allele seemed to increase the susceptibility of aggressive periodontitis (odds ratio ? 2.02, 95% confidence interval ? 1.16–3.50) in Chinese patients. There was no significant difference in the genotype distribution or the allele frequencies of vitamin D receptor BsmI, ApaI and TaqI between two groups.
Conclusion: The study indicates that FokI polymorphism of vitamin D receptor gene might be associated with generalized aggressive periodontitis in Chinese patients. In addition, the carriage of F allele increases the risk of developing generalized aggressive periodontitis.
Key words: vitamin D receptor; aggressive periodontitis;polymorphism; susceptibility

1浏览PDF格式全文需要使用软件--Abode Acrobat(由于软件较大并常见,我站不提供下载)

2、下载论文全文请点击鼠标右键“另存为”或使用断点续传软件下载(81KB)


本站收录的本文作者的其他论文:

1、维生素D受体基因多态性与牙周炎易感性关系的研究进展

2、取根管内折断器械的并发症

3、维生素D受体基因TaqI位点多态性与慢性牙周炎易感性关系的Meta分析

4、维生素D受体基因FokⅠ位点多态性与汉族人群中重度牙周炎易感性的关系

5、固齿丸对中、重度牙周炎患者血清骨代谢的影响

6、牙周科老年患者系统性疾病情况调查

 更多相关论文请点击本站的<<<站内全文搜索>>>查找

 

欢迎您参加讨论,发表您对此论文及其研究领域的看法!
(请在发言时在标题中使用所点评的论文的题目或研究方向,这样方便大家浏览!)

返回首页 | CIMS论文 | 并行工程 | 虚拟制造 | 敏捷制造 | 其他论文 | 项目开发 | 学术资源 | 站内全文搜索 | 免费论文网站大全 |

line.gif (4535 字节)

为了更好的为大家服务,欢迎您参加本站的投票调查

>>>>参加更多投票调查请点击!

本站永久域名:http://www.cimspaper.com欢迎访问

注意:本站内容未经书面允许不得转载

All rights reserved, all contents copyright 2000-2019
本站自2000年3月总网页访问量为