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维生素D受体基因FokⅠ位点多态性与汉族人群中重度牙周炎易感性的关系

注意：本论文已在《牙体牙髓牙周病学杂志》, 2007, 17(8):448-451发表
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李　升1 ,杨明华1 ,王玉才2 ,吴文蕾1 ,黄晓峰1 ,钱海峰1
(江苏南京: 1. 南京大学医学院附属口腔医院, 210008;
2. 南京大学医学院临床学院·南京军区南京总医院, 210002)

摘要:目的:探讨维生素D 受体(VDR) 基因FokⅠ位点多态性与汉族人群中重度慢性牙周炎 (CP) 易感性的关系。方法:搜集汉族中重度牙周炎病人71例,并以50例牙周健康者作为对照组,均采外周静 脉血提取基因组DNA,采用聚合酶链反应- 限制性片段长度多态性( PCR - RFLP)方法测定FokⅠ基因型,并分 析组间基因型和等位基因频率的差异。结果: CP组的基因型分布情况为: FF (24, 33. 8% ) , Ff (38, 53. 5% ) 和ff (9, 12. 7% ) ,对照组为: FF ( 9, 18% ) , Ff ( 26, 52% ) 及ff ( 15, 30% ) , 组间比较有显著性差异(χ2 = 7. 14, P = 0. 028) 。CP组等位基因频率为F (60. 6% ) , f (39. 4% ) ,对照组为F (44% ) , f (56% ) ,组间比较有显著性差 异(χ2 = 6. 48, P = 0. 011) 。FF基因型相对于( Ff + ff)的OR = 2. 33 (95%CI = 0. 97 - 5. 57) ; F等位基因相对于f 的OR = 1. 95 (95%CI = 1. 16 - 3. 28) 。结论:VDR基因FokⅠ位点多态性与汉族人中重度牙周炎易感性可能存 在一定的联系。
关键词: 维生素D受体; 基因多态性; 牙周炎; 易感性
[中图分类号] R781. 4　　　[文献标识码]A 　　　[文章编号]1005 - 2593 (2007) 08 - 0448 - 04

Association of vitam in D receptor gene fokⅠpolymorphism with moderate to severe chron ic per iodontitis of han nationality

ABSTRACT:A IM : To investigate the association of vitamin D recep tor gene FokⅠ polymorphism with moderate to severe chronic periodontitis of Han Nationality. METHODS: A restriction fragment length polymorphism (RFLP) for FokⅠ of the VDR gene was analyzed by polymerase chain reaction ( PCR) , followed by restriction digestion with FokⅠ and gel electrophoresis. The genotypes of 71 moderate severe cases of periodontitis and 50 controlswith no periodontitis were analyzed. RESULTS: The genotype distribution in the patient group were 24 ( 33. 8% ) , 38 (53. 5% ) and 9 (12. 7% ) and in the control group were 9 (18% ) , 26 (52% ) and 15 (30% ) for FF, Ff and ff respectively. Allele frequencies were 60. 6% and 39. 4% for F and f in the patient group; 44% and 56% in the control group. Chi square analysis indicated that the distribution of the genotypes and alleles between these two group swere sig nificantly different ( P = 0. 028, P = 0. 011, respectively). The F allele seemed to increase suscep tibility to chronic periodontitis (OR = 1. 95, 95%CI = 1. 16 - 3. 28). CONCLUS ION: It indicated that okⅠpolymorphism of VDR gene was associated with chronic periodontitis of Han nationality.
Key words :vitamin D recep tor; polymorphism; chronic periodontitis; suscep tibility

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